Yes, you can use the throttle exclusively—that's what it's designed for! However, if you use the throttle the entire time you're riding, it will affect the battery life, allowing you to travel 20-30 miles on a full charge. Additionally, if you use the bike in the summer when temperatures are higher, the controller has features that monitor the temperature. If it detects overheating, it will either reduce the power output or temporarily disable it to prevent damage.
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